Evaluation of efficacy and safety of betahistine dihydrochloride in dogs with vestibular disturbances.

Authors

  • Alexandre Martini Brum Universidade de franca
  • João Paulo da Exaltação Pascon FCAV-UNESP/Jaboticabal
  • Tatiana Champion FCAV-UNESP/Jaboticabal
  • Mirela Tinucci-Costa FCAV-UNESP/Jaboticabal

DOI:

https://doi.org/10.3738/na.v1i2.277

Keywords:

cão, síndrome vestibular, betaistina

Abstract

Vestibular disease is in dogs and cats, and it may be the result of central or peripheral disease. The pathophysiology is unknown, however it can be related to an abnormal dynamic of endolymphatic fluid or neuritis of the vestibular portion of the VIII cranial nerve. The recovery of neurological sings is slow and, in chronic cases, the neurological deficits can be irreversible. The betahistine dihydrochloride is a drug used in humans with peripheral vestibular disorders and was used in four dogs with vestibular syndrome. The results showed clinical improvement in 7 to 10 days of treatment and completed recovery in 20 to 30 days. One year after the treatment, the dogs didn’t have recurrence of the syndrome. The use of betahistine dihydrochloride in dogs with peripheral vestibular syndrome shows rapid clinical recover, without laboratorial abnormalities or recurrence of the clinical signs.

Author Biographies

  • Alexandre Martini Brum, Universidade de franca
    Formado em Medicina Veterinária na UFRGS em 2003. Residência em Clínica Médica de pequenos Animais na UNESP/Jaboticabal entre 2003 a 2005. Mestre em Clínica Veterinária pela UNESP/Jaboticabal em 2007. Atualmente doutorando na UNESP/Jaboticabal, na área de nefrologia de pequenos animais e professor da UNIFRAN, nas disciplinas de Çlínica Médica e Terapêutica de Pequenos Animais e LAboratório Clínico Veterinário.
  • João Paulo da Exaltação Pascon, FCAV-UNESP/Jaboticabal
    Doutorando do Programa de Medicina veterinária da FCAV-UNERSP/Jaboticabal
  • Tatiana Champion, FCAV-UNESP/Jaboticabal
    Doutorando do Programa de Medicina veterinária da FCAV-UNERSP/Jaboticabal
  • Mirela Tinucci-Costa, FCAV-UNESP/Jaboticabal
    Docente do Deparatmento de Clínica e Cirurgia Veterinária

Published

2009-12-08

Issue

Section

Artigos

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