MECHANISM ANTILUTEOLYTIC: PHYSIOLOGY AND STRATEGIES

Abstract

Death in the production of ruminant embryo is still a major obstacle, especially in programs of IATF and recipients of embryo. In the initial stage of pregnancy, called the critical period, which occurs in more than 70% of losses, this time a series of reactions occur so that there is a physiological adjustment of pregnant to not pregnant, the maternal recognition of pregnancy in which the concept must signal its presence by inteferon release of tau to inhibit the programmed discharge of prostaglandin 2 alpha. The progesterone produced by the corpus luteum is one of the factors that go down to oxytocin binds to its receptors stimulated by the action of estrogen receptors in stimulating the production of PGF2? to cause luteolysis. The IFN-? produced by the concept binds to endothelial cells in the endometrium prevents the production of PGF2? and luteolysis. To improve the rates of embryo death is necessary to make development of anti-luteolíticas, to reduce the levels of estrogen to minimize the stimulus in OTCR, controlling the release of PGF2?, slowing or blocking the luteolysis aumentandar or the concentration of circulating progesterone this same period. Increasing the concentration of P4, use of hCG, GnRH and ECG, are strategies to stimulate the mechanism of anti-luteolysis, and strategies involving use of specific diets among others.